This time series dataset includes viral COVID-19 laboratory test [Polymerase chain reaction (PCR)] results from over 1,000 U.S. laboratories and testing locations including commercial and reference laboratories, public health laboratories, hospital laboratories, and other testing locations. Data are reported to state and jurisdictional health departments in accordance with applicable state or local law and in accordance with the Coronavirus Aid, Relief, and Economic Security (CARES) Act (CARES Act Section 18115).